{"id":5133,"date":"2026-01-25T15:18:48","date_gmt":"2026-01-25T21:18:48","guid":{"rendered":"https:\/\/zogen.mx\/?p=5133"},"modified":"2026-01-25T15:18:48","modified_gmt":"2026-01-25T21:18:48","slug":"movember-and-the-importance-of-genomic-studies-in-mens-health-and-cancer","status":"publish","type":"post","link":"https:\/\/zogen.mx\/en\/movember-y-la-importancia-de-los-estudios-genomicos-en-la-salud-masculina-y-el-cancer\/","title":{"rendered":"Movember and the importance of genomic studies in men&#039;s health and cancer"},"content":{"rendered":"<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-1024x576.jpg\" alt=\"\" class=\"wp-image-5139\" srcset=\"https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-1024x576.jpg 1024w, https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-300x169.jpg 300w, https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-768x432.jpg 768w, https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-1536x864.jpg 1536w, https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11-600x338.jpg 600w, https:\/\/zogen.mx\/wp-content\/uploads\/2025\/11\/genes-stock-11.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every November,&nbsp;<strong>Movember<\/strong>&nbsp;It&#039;s driving an urgent conversation: men&#039;s health needs more prevention, early detection, and science. While the movement has brought visibility to issues like prostate and testicular cancer and mental health, it still needs to integrate a crucial component:&nbsp;<strong>Genomics as a clinical tool to prevent, diagnose and treat cancer in men.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The data points to a compelling reality:&nbsp;<strong>Men are diagnosed later than women, avoid medical consultations more frequently, and undergo fewer preventative tests.<\/strong>&nbsp;(Cleveland Clinic, 2023). Movember reminds us that changing this story is not only necessary, but possible.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Cancer in men: an evidence-based overview<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Prostate cancer is the most frequently diagnosed cancer in men worldwide.<\/strong>, with more than 1.4 million new cases in 2022 (IARC\/WHO, GLOBOCAN 2022).<\/li>\n\n\n\n<li><strong>It is the second leading cause of cancer death in men globally.<\/strong>, second only to lung cancer (IARC\/WHO, 2022).<\/li>\n\n\n\n<li><strong>1 in 8 men will develop prostate cancer at some point in their lives<\/strong>\u00a0(American Cancer Society, 2023).<\/li>\n\n\n\n<li><strong>Lung cancer accounts for 21.51% of all cancer deaths in the male population<\/strong>\u00a0(GLOBOCAN 2022).<\/li>\n\n\n\n<li>He\u00a0<strong>Testicular cancer is the most common solid tumor in men aged 15 to 35.<\/strong>\u00a0(NIH \u2013 National Cancer Institute, 2024).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Beyond the incidence, there is a critical phenomenon:&nbsp;<strong>Many cancers in men do not present symptoms in early stages<\/strong>, especially prostate, liver and lung, which delays diagnosis and reduces therapeutic options (JAMA Oncology, 2023).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Genetics: the silent factor behind cancer in men<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A significant percentage of male cancers have a&nbsp;<strong>hereditary component<\/strong>, This means that risk can be identified even before disease exists.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\ud83d\udccc Key facts about genetics and cancer in men:<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Between 5-10% of prostate cancers are hereditary<\/strong>\u00a0(NCI, 2024).<\/li>\n\n\n\n<li>The carriers of\u00a0<strong>Mutations in BRCA2 have up to an 8.6 times greater risk of developing aggressive prostate cancer<\/strong>\u00a0compared with the general population (Castro et al., NEJM 2022).<\/li>\n\n\n\n<li>Men with mutations\u00a0<strong>BRCA1\/BRCA2 also have an increased risk of male breast cancer, pancreatic cancer, and melanoma<\/strong>\u00a0(Lancet Oncology, 2023).<\/li>\n\n\n\n<li><strong>Variants in HOXB13 are associated with a significant increase in the risk of early-onset prostate cancer<\/strong>\u00a0(Ewing et al., NEJM 2021).<\/li>\n\n\n\n<li>The incorporation of genomic testing in oncology\u00a0<strong>impacts therapeutic decisions in more than 601% of patients with advanced cancer<\/strong>\u00a0(ASCO \u2013 American Society of Clinical Oncology, 2023).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This changes the paradigm: detection depends not only on symptoms, but also on&nbsp;<strong>Understanding the patient&#039;s DNA and their actual risk<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What can genomic studies reveal in male oncology?<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1.\u00a0<strong>Hereditary risk (personalized prevention)<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">They allow you to answer questions such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can I develop cancer even if I feel healthy?<\/li>\n\n\n\n<li>Could cancer in my family affect my children?<\/li>\n\n\n\n<li>Do I need to start checkups earlier than the general population?<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Clinically relevant genes include:<br><strong>BRCA1, BRCA2, ATM, CHEK2, PALB2, HOXB13, MLH1, MSH2, MSH6<\/strong>, among others (NCCN Guidelines 2024).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"> 2.\u00a0<strong>Tumor genomic profiling (precision treatment)<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Analyze the tumor&#039;s DNA to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Choosing targeted therapies<\/li>\n\n\n\n<li>Avoid treatments with a low probability of success<\/li>\n\n\n\n<li>Access to specific immunotherapy or clinical trials<\/li>\n\n\n\n<li>Personalizing therapeutic decisions based on biomarkers<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The use of genomics&nbsp;<strong>Improves clinical outcomes in advanced cancers<\/strong>, especially in prostate, lung and metastatic solid tumors (JAMA Oncology, 2023).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Movember: It&#039;s no longer just about awareness, it&#039;s about clinical action<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Men&#039;s health prevention has evolved. It is no longer limited to:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2714 Better habits<br>\u2714 Annual checkups<br>\u2714 Identify symptoms<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Today includes:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2714&nbsp;<strong>assess genetic risk before the disease<\/strong><br>\u2714&nbsp;<strong>personalize DNA-based treatments<\/strong><br>\u2714&nbsp;<strong>to make medical decisions with accurate molecular information<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As the scientific literature points out:<br><strong>Genomic medicine is not the future; it is an emerging standard of care in oncology.<\/strong>&nbsp;(ASCO, 2023; JCO Precision Oncology, 2024).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Who should consider a genomic study this Movember?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u2705 Men with family members with cancer (prostate, breast, pancreas, colon, ovary)<br>\u2705 Early stage cancer diagnosis (&lt;55 years)<br>\u2705 Aggressive or treatment-resistant tumors<br>\u2705 Families with multiple cases of cancer across generations<br>\u2705 Cancer patients seeking personalized treatment options<br>\u2705 Men who want to know their hereditary risk<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Talking about cancer in men without talking about genetics is only telling part of the story.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This&nbsp;<strong>Movember<\/strong>, The message is clear:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li> More early detection<\/li>\n\n\n\n<li> Fewer taboos<\/li>\n\n\n\n<li>More science<\/li>\n\n\n\n<li>And more genomics applied to real-world decisions<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Because today,&nbsp;<strong>The smartest prevention is the one that reads the DNA before the symptoms.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you or a family member has received a diagnosis or has suspicions, contact us and receive free advice.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>References<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>International Agency for Research on Cancer (IARC\/WHO).\u00a0<em>GLOBOCAN 2022.<\/em><\/li>\n\n\n\n<li>American Cancer Society.\u00a0<em>Cancer Facts &amp; Figures 2023.<\/em><\/li>\n\n\n\n<li>Castro E., et al.\u00a0<strong>NEJM<\/strong>, 2022;\u00a0<em>BRCA2 and aggressive prostate cancer risk.<\/em><\/li>\n\n\n\n<li>National Cancer Institute (NCI).\u00a0<em>Genetics of Prostate Cancer<\/em>, 2024.<\/li>\n\n\n\n<li>Ewing et al.\u00a0<strong>NEJM<\/strong>, 2021;\u00a0<em>HOXB13 and early-onset prostate cancer<\/em>.<\/li>\n\n\n\n<li>DISGUST.\u00a0<em>Precision Medicine in Oncology Report<\/em>, 2023.<\/li>\n\n\n\n<li>JAMA Oncology, 2023.\u00a0<em>Genomic profiling impact on advanced cancers.<\/em><\/li>\n\n\n\n<li>Cleveland Clinic, Men&#039;s Health Statistics, 2023.<\/li>\n\n\n\n<li>NCCN Guidelines: Genetic\/Familial High-Risk Assessment, 2024.<\/li>\n\n\n\n<li>Lancet Oncology, 2023.\u00a0<em>BRCA variation in male cancer populations.<\/em><\/li>\n\n\n\n<li>JCO Precision Oncology, 2024.\u00a0<em>Implementation of genomics in clinical care.<\/em><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Cada noviembre,&nbsp;Movember&nbsp;impulsa una conversaci\u00f3n urgente: la salud masculina necesita m\u00e1s prevenci\u00f3n, detecci\u00f3n temprana y ciencia. Aunque el movimiento ha visibilizado temas como el c\u00e1ncer de pr\u00f3stata, testicular y la salud mental, a\u00fan falta integrar un componente decisivo:&nbsp;la gen\u00f3mica como herramienta cl\u00ednica para prevenir, diagnosticar y tratar el c\u00e1ncer en hombres. Los datos se\u00f1alan una realidad [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5139,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Movember y la importancia de los estudios gen\u00f3micos en la salud masculina y el c\u00e1ncer - zogen<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zogen.mx\/en\/movember-and-the-importance-of-genomic-studies-in-mens-health-and-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Movember y la importancia de los estudios gen\u00f3micos en la salud masculina y el c\u00e1ncer - zogen\" \/>\n<meta property=\"og:description\" content=\"Cada noviembre,&nbsp;Movember&nbsp;impulsa una conversaci\u00f3n urgente: la salud masculina necesita m\u00e1s prevenci\u00f3n, detecci\u00f3n temprana y ciencia. Aunque el movimiento ha visibilizado temas como el c\u00e1ncer de pr\u00f3stata, testicular y la salud mental, a\u00fan falta integrar un componente decisivo:&nbsp;la gen\u00f3mica como herramienta cl\u00ednica para prevenir, diagnosticar y tratar el c\u00e1ncer en hombres. 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Aunque el movimiento ha visibilizado temas como el c\u00e1ncer de pr\u00f3stata, testicular y la salud mental, a\u00fan falta integrar un componente decisivo:&nbsp;la gen\u00f3mica como herramienta cl\u00ednica para prevenir, diagnosticar y tratar el c\u00e1ncer en hombres. 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