{"id":1475,"date":"2026-01-25T15:18:49","date_gmt":"2026-01-25T21:18:49","guid":{"rendered":"https:\/\/zogen.local\/?p=1475"},"modified":"2026-01-25T15:18:49","modified_gmt":"2026-01-25T21:18:49","slug":"genes-and-chromosomes","status":"publish","type":"post","link":"https:\/\/zogen.mx\/en\/genes-y-cromosomas\/","title":{"rendered":"Genes and chromosomes"},"content":{"rendered":"<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/zogen.local\/wp-content\/uploads\/2024\/09\/genes-stock-3-1024x576.jpg\" alt=\"\" class=\"wp-image-1476\" srcset=\"https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-1024x576.jpg 1024w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-300x169.jpg 300w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-768x432.jpg 768w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-1536x864.jpg 1536w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-640x360.jpg 640w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-400x225.jpg 400w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-367x206.jpg 367w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3-600x338.jpg 600w, https:\/\/zogen.mx\/wp-content\/uploads\/2024\/09\/genes-stock-3.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">DNA, or deoxyribonucleic acid, is a complex molecule found in every cell of our body, containing the instructions necessary to create and maintain life. It is primarily composed of four chemical substances: adenine (A), thymine (T), guanine (G), and cytosine (C), which pair in a very specific way: A with T, C with G. Along these sequences of &quot;letters,&quot; we can distinguish certain segments known as genes, which contain the information necessary to produce proteins that, as we will see below, are essential for the proper functioning of the organism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The complete set of DNA, that is, our genetic material, is called the genome. With few exceptions, every cell in the body contains a copy of our entire genome. If we think about it, we might imagine that all our DNA is a single, very long molecule. However, this is not the case, as it is divided into a series of unequal segments that, thanks to other molecules, are compacted and form what we know as chromatin. When cells divide, the chromatin reaches its highest degree of compaction, forming chromosomes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Chromosomes<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As you just saw, chromosomes are compacted packages of DNA. In humans and other organisms, they are not found free in the cell, but are contained within a structure called the cell nucleus.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DNA contains the instructions necessary to create and maintain life, so, as you can imagine, each organism contains a different number of chromosomes. For example, a dog&#039;s cells contain 78 chromosomes, and an elephant&#039;s cells contain 56.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A curious fact: one of the organisms with the most chromosomes that we know of are ferns, which have more than 100 chromosomes, and the one with the fewest is the ant Myrmecia pilosula, which only has one.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>How many chromosomes do humans have?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Well, in our case, each human cell has 46 chromosomes, organized into 23 pairs. That is, we have two copies of each chromosome, one from our father and one from our mother. This occurs in all the cells of our body, except for sex cells, that is, eggs and sperm, which contain only 23 chromosomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This makes it possible that, when both cells (egg and sperm) unite, a zygote is formed which will give rise to an embryo whose cells will have the 23 pairs of chromosomes, one copy of which is from each parent.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Are chromosomes the same?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Each chromosome contains information with different instructions for the maintenance and functioning of the organism and, therefore, they are different from each other.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the case of humans, as we have seen, we have 23 pairs: 22 of them are called autosomes, while the 23rd pair is called the sex chromosome. This differs between the sexes:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 In the case of women, chromosome 23 is composed of two X copies (XX).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 In the case of males, chromosome 23 consists of one X copy and one Y copy (XY).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>How are chromosomes formed?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As we have seen, DNA molecules are very long, so the formation of chromosomes is essential for cell division. Logically, both resulting cells must have the same genetic information, so when cells divide, the genetic information is duplicated before forming two daughter cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DNA is shaped like a double helix. Imagining a spiral staircase can help you visualize it. It is found in the cell nucleus, where the double helix folds around proteins called histones and forms a structure called a nucleosome.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Nucleosomes and chromatin<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">These nucleosomes (double helices folded around a set of proteins) gradually come together and form a structure resembling a string of beads, which continues to compact further until it generates another structure called chromatin, in which other molecules (proteins and RNA) participate. When chromatin reaches its maximum degree of compaction, it gives rise to chromosomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">When a cell divides, as mentioned earlier, the genetic information is duplicated and X-shaped chromosomes are formed, which are visible under a microscope. If we take a picture of the nucleus and then arrange the chromosomes in pairs, we can obtain what is called a karyotype, in which the chromosomes look like this:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.veritasint.com\/blog\/wp-content\/uploads\/2024\/06\/Karyotype-768x432.jpg\" alt=\"\" class=\"wp-image-2822\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.genome.gov\/genetics-glossary\/Karyotype\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">But if we want to take a closer look at a chromosome, this is the structure we would find:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.veritasint.com\/blog\/wp-content\/uploads\/2024\/06\/Captura-de-pantalla-2024-06-10-a-las-15.42.15-705x768.png\" alt=\"\" class=\"wp-image-2824\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.genome.gov\/genetics-glossary\/Centromere\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Types of chromosomes based on the centromere<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As we can see in the image, when a cell is about to divide, the chromosomes are made up of two sister chromatids, which contain the same genetic information. These are joined by a constriction called the centromere, which, as we can see, divides the chromatids into arms. The length of the chromatid arms depends on the location of the centromere on the chromosome. Based on this, there are different types of chromosomes, which we explain below:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Metacentric chromosome: the centromere is in the middle of the chromosome, and both arms of the chromatid are of equal length.<\/li>\n\n\n\n<li>Submetacentric chromosome: the centromere is slightly separated from the center, so that one arm of the chromatid is longer than the other.<\/li>\n\n\n\n<li>Acrocentric chromosome: the centromere is almost at the end of the chromosome, so one arm is much smaller than the other.<\/li>\n\n\n\n<li>Telocentric chromosome: the centromere is at the end of the chromosome, so only one arm is visible.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Centromeres have an essential function, since during cell division they participate in the correct alignment and distribution of chromosomes to daughter cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Telomeres, structures related to aging<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Telomeres are located at the ends of chromosomes. These structures are involved in chromosome stability, as they prevent chromosomes from breaking or becoming damaged. This function is very important, since studies show that telomere length decreases as cells divide. This telomere shortening is associated with aging.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Pathologies associated with chromosomes<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Have you ever heard that Down syndrome is caused by a chromosomal abnormality? This is indeed the case, as errors sometimes occur in sex cells or during embryonic development, leading to chromosomal abnormalities. This can result in a miscarriage or cause the newborn to have certain health conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Specifically, in the case of Down syndrome, a trisomy occurs; that is, the cells of people with this syndrome generally have three copies of chromosome 21, so they have a total of 47 chromosomes instead of the expected 46. This is known as a numerical chromosomal abnormality, which in this case is caused by a gain. However, we can also find cases of monosomy, in which a chromosome is lost, as in Turner syndrome, where a copy of the X chromosome is lost.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to numerical abnormalities, structural abnormalities can also occur, where a fragment of a chromosome breaks off and is relocated, is lost, or is duplicated, among other things, resulting in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Deletion: a loss of genetic material.<\/li>\n\n\n\n<li>Duplication: a duplication of part of a chromosome.<\/li>\n\n\n\n<li>Insertion: insertion of part of a chromosome in an unusual position, either within the same chromosome or a different chromosome.<\/li>\n\n\n\n<li>Inversion: part of a chromosomal fragment at two points and, when it is rejoined, it does so in reverse.<\/li>\n\n\n\n<li>Translocation: a change in the location of chromosomal material.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.veritasint.com\/blog\/wp-content\/uploads\/2024\/06\/ChrAbnormalities_Fact-sheet2020-768x432.jpg\" alt=\"\" class=\"wp-image-2826\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.genome.gov\/about-genomics\/fact-sheets\/Chromosome-Abnormalities-Fact-Sheet\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Chromosomal analytes<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Types of DNA<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We can make different classifications depending on location or function. As we&#039;ve been discussing throughout this post, genetic material is found in the cell nucleus, but we can also distinguish another type of DNA: mitochondrial DNA. As its name suggests, this DNA is found in the mitochondria, the organelles responsible for providing energy to cells. Unlike nuclear DNA, this DNA is small (composed of about 16,500 base pairs) and is not organized into segments. Instead, the double helix is supercoiled and closes upon itself, giving it a circular shape. It is composed of 37 genes that encode proteins that perform their functions within the mitochondria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the other hand, when we talk about nuclear DNA, we must differentiate between two types of DNA: coding DNA and non-coding DNA. Let&#039;s look at them in detail.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>non-coding DNA<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Surprisingly, non-coding DNA makes up about 99% of our entire genome. But we shouldn&#039;t confuse non-coding with non-functional. In other words, these DNA sequences don&#039;t produce proteins, but they have many other functions, such as gene activation and DNA packaging.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>DNA and gene coding<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As we explained at the beginning, within the DNA sequence we find specific regions known as genes. It is in these regions that we find coding DNA, that is, the sequences that contain the information to form other molecules called proteins that have different functions, such as, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Structural proteins: essential molecules that form part of the body&#039;s structures, in addition to carrying out various functions.<\/li>\n\n\n\n<li>Enzymes: a type of protein that participates in the process of cellular reactions.<\/li>\n\n\n\n<li>Transcription factors: proteins involved in the regulation of other genes.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>From genes to proteins<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The process by which a gene gives rise to a protein can be divided into two main phases, and is part of the central principle of molecular biology:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Transcription: DNA is transcribed, creating an RNA (ribonucleic acid) molecule. This process is a bit more complex than it first appears. The DNA sequence that is transcribed is, as we saw earlier, a gene. Within the gene, two regions are distinguished: exons and introns. Exons are the regions of DNA that strictly code for a protein, while introns do not. For this reason, the RNA molecule must undergo a maturation process to produce messenger RNA (mRNA), in which the intronic sequences are removed, leaving only the exons that will be translated into a protein.<\/li>\n\n\n\n<li>Translation: This mRNA is transported out of the nucleus to a structure in the cell called a ribosome, which reads the RNA sequence and generates the sequence of amino acids, the basic structural unit of proteins, in a very specific way, since every three &quot;letters&quot; of RNA are translated into one &quot;letter&quot; of the protein. Like a language, there is a genetic code that determines the translation of genes into proteins.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In many cases, protein synthesis does not end here, but requires modifications so that it can acquire its final conformation and, with it, perform its function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>The promoter, the key to activating or deactivating a gene<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This protein synthesis process doesn&#039;t happen randomly, nor does it occur with all genes simultaneously in the organism. It&#039;s important to know that genes, in addition to introns and exons, have a sequence called a promoter, which is located before the gene sequence where transcription begins. The promoter is the sequence necessary for a gene to be activated, as the transcription process starts at this point.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The process of gene expression is highly regulated as cells synthesize and stop protein synthesis when appropriate. This is called gene regulation, which is the process of turning genes on and off. It is a very complex mechanism involving different molecules and processes. One of the most studied aspects is epigenetics.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Epigenetics<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">DNA displays epigenetic marks such as DNA methylation and histone modification, among others. These change how genes are expressed. Every cell type has specialized epigenetic patterns.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are also proteins that activate or deactivate certain genes by binding to areas near them, called transcription factors. If transcription factors promote transcription, they are called activators, while if they decrease transcription, they are called repressors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As we have already seen, not all species and organisms have the same number of chromosomes, and the same is true for the number of genes. While humans have approximately 20,000 genes, for example, the fruit fly contains around 13,500, and a recent study sequenced a small crustacean, the water flea (Daphnia pulex), indicating that it has around 31,000 genes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Genes, responsible for our distinctive traits<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Now that we know what a gene is and how the information it contains gives rise to the processes and mechanisms of our organism, let&#039;s talk about the phenotype, which we can define as the observable traits of a person.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As we have seen, genes give rise to proteins that perform a large number of functions in our bodies. These functions are not only metabolic; the color of our eyes, our height, and even our predisposition to snack between meals depend on the information contained in our genes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Environmental factors in gene expression<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Although we can link a genotype to a trait, in general all these factors are multifactorial. That is, genetics plays a very important role in determining these traits, but there are other external factors such as diet, smoking, or exercise that affect how the trait manifests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>0.1%, the small number that makes us unique<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As you know, 99.9% of the % gene in our genome is the same in all humans, but that 0.11% is what makes us unique. In terms of traits, have you ever wondered why some people have a sweet tooth, or why others are better at endurance sports? Well, it&#039;s this tiny percentage that also accounts for these differences among us.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We hope this article has helped you better understand how genes and chromosomes work, which, as you have seen, are fundamental to defining who we are.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Can you imagine being able to read every letter that makes up your genetic information and learn interesting facts about yourself, such as whether you have a greater tendency to snack between meals, as well as your risk of certain diseases? In short, can you imagine being able to know all the information your genes contain about you?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Today, it&#039;s possible: now you have the opportunity to read the great book of your genes, something that was unthinkable just a few years ago. With the test\u00a0<strong><a href=\"https:\/\/zogen.local\/product\/mi-genoma\/\">My Genome<\/a><a href=\"https:\/\/www.veritasint.com\/mygenome\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0<\/a><\/strong>You can sequence your entire genome and discover what your genes say about you. Could there be any more valuable information than that?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source: https:\/\/www.veritasint.com\/blog\/en\/genes-and-chromosomes-how-do-they-determine-our-life-and-health\/<\/p>","protected":false},"excerpt":{"rendered":"<p>El ADN, el \u00e1cido desoxirribonucleico (ADN) es una mol\u00e9cula compleja que se encuentra en cada c\u00e9lula de nuestro cuerpo, que contiene las instrucciones necesarias para crear y mantener la vida. Se compone principalmente de cuatro sustancias qu\u00edmicas: adenina (A), timina (T), guanina (G) y citosina (C), que se unen de una manera muy espec\u00edfica: A [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":1476,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genes y cromosomas - zogen<\/title>\n<meta name=\"description\" content=\"Entre genes y cromosomas, y c\u00f3mo su interacci\u00f3n define nuestras caracter\u00edsticas. 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